QT shift and probabilistic method: powerful approaches for detection of QT prolongation in a most reliable manner. >>>
TDPscreen: in silico modeling for prediction of torsadogenic profiles
Founded in 1973, CERB has developed to a leading international contract research organization (CRO) in the fields of preclinical pharmacology and toxicology. Taking on the challenges of modern drug development CERB has created its distinctive image of a major service provider to the pharmaceutical industry in the context of innovative biomedical research.
Our toxicology department has also proven to be a valuable partner to other branches, such as chemical and agro-chemical industries, in the field of regulatory safety assessment.
For the pharmaceutical industry, CERB takes advantage of its sophisticated synergy between pharmacology and toxicology resources to provide complete pre-phase I packages for a new molecule in an economic and timely manner. Having developed/validated more than 200 models and techniques in pharmacology and toxicology we take on any challenge of specialized approaches fitting the requirements of your compound. A fully equipped chemical analysis unit assures back-up support for drug quantification in chemical or biological matrices as well as biomarker verification.
Our main assets are:
- high quality of scientific and administrative performance
- continuous innovation through targeted scientific input
- a network of independent, internationally renowned experts and cooperations
- the dedication to provide custom-made answers
- reactivity and flexibility
2015 "Short term variability in QT interval and ventricular arrhythmias are dependent on high frequency autonomic oscillations
2014 "Preclinical QT safety assessment: Cross-species comparisons and human translation from an industry consortium" >>>
2013 "Power spectral analysis of heart rate variability in cynomolgus monkeys in safety pharmacology studies: Comparative study with beagle dogs" >>>
An in silicotransmural model for arrhythmias originated from the Purkinje network/endocardium interface - SPS 2013 >>>
Improved detection of CNS effects in rats by use of the electrocorticogram - SPS 2012 >>>